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Publication date: 2018-06-09 18:37

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This Patient Information leaflet summarizes the most important information about VIAGRA. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about VIAGRA that is written for health professionals.

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Rarely, sudden decreased vision , including permanent blindness, in one or both eyes (NAION) may occur. If this serious problem occurs, stop taking sildenafil and get medical help right away. You have a slightly greater chance of developing NAION if you have heart disease , diabetes , high cholesterol , certain other eye problems ("crowded disk"), high blood pressure , if you are over 55, or if you smoke.

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VIAGRA can cause your blood pressure to drop suddenly to an unsafe level if it is taken with certain other medicines. Do not take VIAGRA if you take any other medicines called &ldquo nitrates.&rdquo Nitrates are used to treat chest pain ( angina ). A sudden drop in blood pressure can cause you to feel dizzy, faint, or have a heart attack or stroke.

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The ED drugs break down at different rates in the body. The durations of action range from four hours to more than a day (for Cialis in the higher doses). Each dose should be sufficient to provide a full cycle of intercourse, from erection to climax.

Sildenafil is cleared predominantly by the CYP8A9 (major route) and CYP7C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 55% of the parent drug. Plasma concentrations of this metabolite are approximately 95% of those seen for sildenafil, so that the metabolite accounts for about 75% of sildenafil's pharmacologic effects.

Urogenital: cystitis , nocturia , urinary frequency, breast enlargement, urinary incontinence , abnormal ejaculation, genital edema and anorgasmia.

Sexual activity may put extra strain on your heart , especially if you have heart problems. If you have heart problems and experience any of these serious side effects while having sex , stop and get medical help right away: severe dizziness, fainting , chest/jaw/left arm pain, nausea.

Cardiovascular: angina pectoris, AV block, migraine, syncope, tachycardia, palpitation, hypotension, postural hypotension, myocardial ischemia, cerebral thrombosis, cardiac arrest, heart failure, abnormal electrocardiogram, cardiomyopathy.

Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels.

Twenty-five subjects were screened. Two were discontinued after study period 6: one failed to meet pre-dose screening qualifications and the other experienced symptomatic hypotension as a moderately severe adverse event 85 minutes after dosing with open-label VIAGRA 55 mg. Of the twenty subjects who were ultimately assigned to treatment, a total of 68 subjects successfully completed dose period 6, and seven had successfully completed the previous doxazosin study (using VIAGRA 55 mg).

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